教学科研系列

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基本信息

电话: 0715-86102435

地址: School of science, Harbin Institute of Technology (Shenzhen), Guangdong, China

邮箱: youhengzhi@hit.edu.cn

个人简介

游恒志教授,博士生导师,博士毕业于英国牛津大学有机化学专业,师从 Prof. Stephen. Fletcher 教授,在不对称催化与合成领域具有多年的研究基础和工作经验。目前任职于哈尔滨工业大学(深圳),理学院化学学科副主任,同时兼任哈尔滨工业大学 (深圳)绿色制药工程研究院副院长,深圳市先进功能材料与综合应用重点实验室副主任。入选哈工大“青年拔尖人才计划”,深圳市“国家级领军人才计划”,深圳市南山区 A 类“领航人才计划”,深圳市南山区青联委员。


理想,为老百姓提供更便宜、疗效更好的药。


研究方向,结合我国生物医药/制药行业的研发痛点和应用需求,探索研究更加绿色、高效、安全、智能的应用型合成与生产技术。研究特色是非均相催化、Al+ 连续流动化学。具体包括:(1)新型非均相催化剂的设计、合成及其在连续流动合成中的应用研究;(2)基于高通量连续流反应系统平台,应用人工智能算法,在化学合成中的路线设计、反应预测、和参数自优化研究;(3)产业导向的药物中间体、功能分子的连续流生产工艺研究。


迄今为止,作为项目团队负责人主持和完成3项300万以上省部级重大项目:青海省揭榜挂帅项目-青海盐湖工业股份有限公司-连续流工艺甲酸镁途径制备无水氯化镁,深圳市国家级领军人才项目-基于连续流技术的高通量反应和人工智能应用研究,重大企业技术攻关-中核集团深圳市中核海得威生物科技有限公司-同位素原料药XXX的连续生产工艺研究;作为联合承研单位团队负责人,合作攻关了5项1000万以上国家和省部级重大项目:国家级科工局重大专项-XXX连续制备关键技术研究,深圳市创新创业重点项目-重202405004 基于人工智能的全谱药物设计平台关键技术研发,深圳市技术攻关重点项目-重2020N038 心脑血管疾病预防治疗用原料药及制剂关键技术的研发,重20200180 连续多级微反应关键技术研发,深圳市可持续发展重点项目-美容多肽新原料高效绿色制备技术研发;主持其他国家自然科学基金、国家科技部、广东省自然科学基金、深圳市自然科学基金、相关生物医药、精细化工企业等科研项目30余项,项目合同总金额超过 8000 万元;相关成果在国际一流期刊,包括 Nature, J.Am.Chem.Soc,ACS Catalysis,Chem.Sci 等发表共计 40余 篇高水平SCI论文,申请或授权 70 余项国际/国家发明专利。


个人ORCID网站, https://orcid.org/0000-0001-8904-5050


招生招聘

每年拟招收有机、化工、计算机等相关方向硕士研究生2-3名,博士研究生1-2名,长期招聘研究助理、博士后研究员,年薪人民币不低于40万元;欢迎对生物医药行业前沿技术,例如连续流动合成、人工智能应用等感兴趣的有志同学和青年加入!

工作经历

2018.09 - 至今                   中国       哈尔滨工业大学(深圳),教授、博导

2017.04 - 2018.09            美国/英国   Vertex Pharmaceuticals(VRTX),Vertex Fellow

学习经历

2024.09 -  至今                  中国    北京大学    光华管理学院,在职研究生

2012.10 - 2017.02             英国    牛津大学    有机化学,博士学位

2008.09 - 2012.07             中国    上海大学    应用化学,学士学位

教学经历

有机化学A,理学院,本科生公共基础课,哈尔滨工业大学(深圳)

有机化学,材料学院/ 环境学院,本科生公共基础课,哈尔滨工业大学(深圳)

有机化学实验 ,材料学院/ 环境学院,本科生公共基础课,哈尔滨工业大学(深圳)

Advanced Organic Chemistry, 理学院,硕博核心必修课,哈尔滨工业大学(深圳),全英文授课

有机合成前沿讲座 ,理学院,硕博选修课,哈尔滨工业大学(深圳)

研究生科学素养,理学院,硕博核心必修课,哈尔滨工业大学(深圳)

功能材料与界面过程前沿讲座,理学院,硕博选修课,哈尔滨工业大学(深圳)

科研项目

国家省市级政府科研项目

2024.12 - 2026.12  深圳市创新创业重大专项,重202405004 基于人工智能的全谱药物设计平台关键技术研发(联合单位主持,黄均荣,团队负责人,游恒志)

2024.12 - 2025.12  广东省惠州市揭榜挂帅项目-信立泰药业有限公司-S086中间体氢化项目(主持,黄均荣,团队负责人,游恒志)

2024.01 - 2026.06  国家级科工局重大专项-XXX连续制备关键技术研究(联合单位负责人)

2024.01 – 2026.11  深圳市可持续发展重大专项,专2023N064 美容多肽新原料高效绿色制备技术研发(联合单位负责人)

2023.09 – 2024.10  国家中组部西部之光访问学者项目,项目号,AK1700000124(主持,刘佳莹,导师,黄玉东/游恒志,已结题)

2023.01 - 2024.12  国家科技部外国专家计划,项目号,110000238320238011(主持,姜梅芬博士后,导师,陈芬儿/游恒志,已结题)

2024.01 - 2026.12  国家自然科学基金-青年科学基金项目,项目号,22302048(主持)

2023.09 - 2025.06  青海省揭榜挂帅项目-青海盐湖工业股份有限公司-连续流工艺甲酸镁途径制备无水氯化镁(主持)

2023.01 - 2024.12  深圳市先进功能碳基材料研究与综合应用重点实验室(核心成员,实验室副主任)

2022.11 - 2023.05  中国博士后科学基金面上项目(主持,贾雪雷博士后,导师,游恒志/沈桂富,已结题)

2022.01 - 2024.12  深圳市基础研究专项(自然科学基金)-稳定支持面上项目(主持,已结题)

2021.10 - 2024.09  广东省青年科学基金项目-广东省基础与应用基础研究基金委员会(主持,已结题)

2021.06 - 2023.12  深圳市科技攻关重大专项,重2020N038 心脑血管疾病预防治疗用原料药及制剂关键技术的研发(联合单位负责人)

2021.01 - 2023.01 深圳市科技攻关重大专项,重20200180 连续多级微反应关键技术研发(联合单位负责人,已结题)

2020.01 - 2023.01  深圳市基础研究专项(自然科学基金)-基础研究面上项目(主持,已结题)

2019.01 - 2021.12  深圳市引进人才科研启动项目(主持,已结题)

2018.12 - 2021.12  哈尔滨工业大学(深圳)青年拔尖人才科研启动项目(主持,已结题)


2024年度企业科研项目

2024.12 - 2027.12  哈工大(深圳)—欧世盛连续流化学校企联合实验室(主持)

2024.11 - 2025.11  信立泰药业有限公司-300吨年产量XXX工艺中试服务合作协议(主持)

2024.06 - 2027.06  哈工大(深圳)—一正科技连续流化学联合实验室(主持)


2023年度企业科研项目

2023.10 - 2025.09  信立泰药业有限公司-SAL0119-E 不对称合成工艺开发(主持)

2023.09 - 2023.12  信立泰药业有限公司-连续流同位素药物中试GMP服务合作协议(主持)

2023.06 - 2026.06  哈工大(深圳)—中核海得威连续制造联合实验室(主持)

2023.06 - 2024.12  深圳市中核海得威生物科技有限公司-同位素原料药XXX的连续生产工艺研究(主持)


2022年度企业科研项目

2022.06 - 2022.12 深圳市一正科技有限公司-连续多级反应器酶催化应用技术研究(主持,已结题)

2022.11 - 2023.06 深圳市中核海得威生物科技有限公司-HDW-XXX连续合成工艺研究-合同编号HDW2022PD0302(主持,已结题)


2021年度企业科研项目

2021.06 - 2021.12 深圳市中核海得威生物科技有限公司-同位素药物XXX连续合成工艺研究-合同编号HDW2021RD0006(主持,已结题)

2021.06 - 2021.12 广东派特埃尔生物科技有限公司-α-酮戊二酸二钠、N-羟甲基甘氨酸、三羟甲基氨基甲烷的连续合成工艺研究(主持,已结题)




学术兼职

2024-至今  深圳市知识产权专家

2023-至今  江西省科技项目评审专家

2023-至今  广东省科技项目评审专家

2023-至今  江苏省科技项目评审专家

2022-至今 《Chinese Chemical Letters》 编委会青年编委

2022-至今 《当代化工研究》 编委会编委

2021-至今  教育部学位中心-学位论文评审专家

2021-至今  深圳市南山区青年委员

2020-至今  中国博士后科学基金评审专家

2020-至今 《Nature communication》《Chemical Science》《ACS Catalysis》《Organic Chemistry Frontiers》《Chemical Communications》《Journal of Flow Chemistry》等国际期刊审稿人

2020-至今 《Green Synthesis&Catalysis》 编委会青年编委

2019-至今  哈尔滨工业大学(深圳)江苏省招生组成员,高考志愿咨询专家

2019-至今  深圳市科创委生物处重大项目评审专家


发明专利

代表性专利

  1. Asymmetric synthesis of chiral compounds. (国际专利).WO2015008097, 2015-1-22.


2024年度专利情况:

国家发明专利,第一发明人

  1. 一种基于分子三维表征的化学反应性预测方法及系统(专利号/申请号:202410248176.2)

  2. 一种基于二维图像分子表征的化学反应性预测方法及系统(专利号/申请号:202410248416.9)

  3. 一种链状外消旋烯丙基醚的不对称烷基化反应的方法(专利号/申请号:202410293100.1)

  4. 一种2-溴-3-(苯丙-2-炔-1-基氧基)苯甲醛及其衍生物的合成方法(专利号/申请号:202410314574.X)

  5. 一种基于1,5-钯迁移反应制备二氢苯并呋喃类化合物的方法(专利号/申请号:202410975276.5)

  6. 一种非均相钯催化选择性铃木偶联反应及其在威罗菲尼中间体合成中的应用(专利号/申请号:202410974779.0)

  7. 一种非均相钯催化的C(sp2)-H 键硅基化反应(专利号/申请号:202410975772.0)

  8. 一种2,2’-双(三甲基硅基)-1,1’-联苯类化合物的合成方法(专利号/申请号:202410975573.X)

  9. 一种基于非均相CPA 催化剂的轴手性N-苯并芳基咪唑的制备方法(专利号/申请号:202411063507.1)


2023年度专利情况:14项国家/国际发明专利

国际发明专利

  1. CONTINUOUS-FLOW SYNTHESIS METHOD OF 13C-UREA,覆盖地区,美国 (专利号/申请号:W22-YXJ-SZZHHD-US-250),联合持有单位,Shenzhen Zhonghe Headway Bio-Sci & Tech Co.,Ltd., Shenzhen, CHINA; Harbin Institute of Technology, Shenzhen, Shenzhen, CHINA;

  2. CONTINUOUS SYNTHESIS SYSTEM OF UREA,覆盖地区,美国 (专利号/申请号:W22-YXJ-SZZHHD-US-251),联合持有单位,Shenzhen Zhonghe Headway Bio-Sci & Tech Co.,Ltd., Shenzhen, CHINA; Harbin Institute of Technology, Shenzhen, Shenzhen, CHINA;

  3. CONTINUOUS-FLOW SYNTHESISMETHOD OF 13C-UREA,覆盖地区,欧洲 (专利号/申请号:EP23165973.1),联合持有单位,Shenzhen Zhonghe Headway Bio-Sci & Tech Co.,Ltd., Shenzhen, CHINA; Harbin Institute of Technology, Shenzhen, Shenzhen, CHINA;

国家发明专利,第一发明人

  1. 一种非均相催化联烯与 1,3-二酮的不对称加成方法(专利号/申请号:202310191362.2,授权号:CN 116425605 B

  2. 一种非均相催化炔烃与叠氮的轴手性 Click 合成方法(专利号/申请号:202310192252.8授权号:CN 116217320 B

  3. 一种非均相催化外消旋烯丙基醇与 1,3-二酮的不对称烯丙基烷基化的方法(专利号/申请号:202310190951.9授权号:CN 116514625 B

  4. 一种高分子负载金属铑的不对称催化剂及其合成方法(专利号/申请号:202310237055.3)

  5. 一种内消旋烯丙基醚的去对称化反应的方法(专利号/申请号:202310190023.2授权号:CN 116217319 B)

  6. 三羟甲基氨基甲烷的制备方法(专利号/申请号:202310939435.1)

  7. 一种高通量筛选系统(专利号/申请号:202310826069.9)

  8. 一种高通量筛选方法(专利号/申请号:202310822825.0)

  9. 一种基于深度学习预训练模型的化学实体识别方法(专利号/申请号:202311105871.5)

  10. 一种连续流法制备三羟甲基氨基甲烷的方法(专利号/申请号:202311121817.X)

  11. 一种四氢喹喔啉衍生物不对称氢化合成方法(专利号/申请号:202311648184.8)


2022年度专利情况:27项国家发明专利

国家发明专利,第一发明人

  1. 一种不饱和羰基或不饱和亚胺化合物的不对称1,4-加成方法(专利号/申请号:202210085186.X,授权号:CN 114456052 B)

  2. 一种二氧化硅负载二茂铁配体及其制备方法(专利号/申请号:202210081349.7,授权号:CN 114539329 B)

  3. 一种高分子负载的不对称催化剂的合成方法(专利号:ZL 202210081358.6,授权号:CN 114539460B)

  4. 一种喹喔啉不对称氢化方法(专利号/申请号:202210699490.3)

  5. 喹喔啉酮不对称氢化方法(专利号/申请号:202210697509.0,授权号:CN 114907277 B)

  6. 一种尿素连续合成系统(专利号/申请号:202210881728.4)

  7. 一种非均相钯催化剂的制备方法及应用(专利号/申请号:202210930180.8,授权号:CN 115193459 B

  8. 一种二氢喹唑啉酮的催化对映选择性合成方法(专利号/申请号:202211126936.X,授权号:CN 115433134 B

  9. 一种高烯丙基醇类化合物的制备方法(专利号/申请号:202211126927.0)

  10. 一种喹啉不对称转移氢化方法(专利号/申请号:202211127057.9,授权号:CN 115448876 B)

  11. 一种自负载型手性磷酸催化剂的合成方法(专利号/申请号:202211113737.5)

  12. 一种来那度胺中间体的制备方法(专利号/申请号:202211151644.1,授权号:CN 115557842 B

  13. 一种连续流法制备安非他酮中间体的方法(专利号/申请号:202211148716.7)

  14. 一种不对称烯丙基烷基化反应的方法(专利号/申请号:202211115323.6,授权号:CN 115583863B)

  15. 一种绿僵菌素B的制备方法(专利号/申请号:202211189862.4)

  16. 一种手性苯乙醇的连续制备方法(专利号/申请号:202211198714.9,授权号:CN 115583865B)

  17. 一种来那度胺的制备方法(专利号/申请号:202211197337.7,授权号:CN 115594660 B)

  18. 一种PseudodestruxinB的制备方法(专利号/申请号:202211208276.X,授权号:CN 115521362 B

  19. 一种不对称烯丙基烷基化反应方法及手性化合物(专利号/申请号:202211273519.8)

  20. 一种以Pd/Al203 为催化剂连续加氢制备四氢叶酸的方法(专利号/申请号:202211577326. 1)

  21. 一种以RaneyNi为催化剂连续加氢制备四氢叶酸的方法(专利号/申请号:202211577312. X)

国家发明专利,共同发明人

  1. 一种13C-尿素的连续流合成方法(专利号/申请号:202210881735.4,授权号:CN 115197100 B)

  2. 一种用于高压系统的固体、浆体连续进料装置(专利号/申请号:202120572255.0)

  3. Pt3Mn/CNTs催化剂的制备方法及该催化剂的应用(专利号/申请号:202211208270.2,授权号:CN 115672321 B)

  4. 一种 Cladoamide A 的制备方法(专利号/申请号:202211360428.8)

  5. 一种缩酚酸肽类天然产物 Isaridin A 的制备方法(专利号/申请号:202210690367.5)

  6. 一种环六脂肽类天然产物 Cladoamide B 的制备方法(专利号/申请号:202210690428.8)


2021年度专利情况:18项国家发明专利

国家发明专利,第一发明人

  1. 一种基于连续流反应器的联芳基化合物的制备方法(专利号/申请号:202111135435.3)

  2. 一种聚苯胺负载贵金属催化剂、连续流反应器及装置(专利号/申请号:202111134504.9, 授权号:CN 113877628 B)

  3. 一种金属缓蚀剂及其制备方法(专利号/申请号:202111182892.8)

  4. 一种不对称烯丙基烷基化反应的连续流反应方法(专利号/申请号:202111039844.3, 授权号:CN 113717019 B

  5. 一种铜催化不对称烯丙基烷基化反应方法及手性化合物(专利号/申请号:202111094341.6,授权号:CN 113816818 B)

  6. 一种N-羟甲基甘氨酸钠的连续流合成工艺(专利号/申请号:202111327461.6,授权号:CN 113956171 B

  7. 一种α-酮戊二酸钠盐的合成工艺(专利号/申请号:202111408535.9)

  8. 一种金属缓蚀剂及其制备方法(专利号/申请号:202111444113.7,授权号:CN 114164430B)

  9. 一种催化加氢制备四氢叶酸的方法 (专利号/申请号:202111453970.3)

  10. 一种四氢叶酸的制备方法(专利号/申请号:202111457715.6, 授权号:CN 114181210 B

国家发明专利,共同发明人

  1. 主动混合连续流反应器和反应系统(专利号/申请号:202110299746.7)

  2. 一种动态混合连续流反应器和多级反应装置(专利号/申请号:202110305297.2)

  3. 连续流反应系统(专利号/申请号:202110299821.X)

  4. 连续多级反应装置(专利号/申请号:202110305174.9)

  5. 连续流反应设备(专利号/申请号:202110991627.8)

  6. 反应装置(专利号/申请号:202110991630.X)

  7. 超重力强化连续反应装置(专利号/申请号:202110991902.6)

  8. 声共振连续流反应装置(专利号/申请号:202110991901.1)


论文及著作


代表性论文
1. You, H., Rideau, E., Sidera, M. & Fletcher, S. P. Non-stabilized nucleophiles in Cu-catalysed dynamic kinetic asymmetric allylic alkylation. Nature. 517, 351–355 (2015).DOI:
10.1038/nature14089

2. Rideau, E., You, H., Sidera, M., Claridge, T. D. W. & Fletcher, S. P. Mechanistic studies on a Cu-catalyzed asymmetric allylic alkylation with cyclic racemic starting materials. J. Am. Chem. Soc. 139, 5614–5624 (2017).DOI: 10.1021/jacs.7b02440

3. Wang, J.,Li, J., Wang, Y., He, S., You, H. & Chen, F. Polymer-Supported Chiral Heterogeneous Copper Catalyst for Asymmetric Conjugate Addition of Ketones and Imines under Batch and Flow. ACS Catal. 9629–9637 (2022). DOI: 10.1021/acscatal.2c02056

4. Jun Li, Xiao Song, Yan Wang, Junrong Huang, Hengzhi You and Fen-Er Chen. Copper-Catalyzed Asymmetric Allylic Alkylation of Racemic Inert Cyclic Allylic Ethers under Batch and Flow. Chemical Science, 2023, 14, 4351–4356, DOI: 10.1039/D3SC00127J

5. Chao Wang, Yan Wang, Xuelei Jia, Junrong Huang, Hengzhi You, Fen-Er Chen. Recyclable Silica-Support Taniaphos/Copper(Ⅰ) complex for asymmetric allylic alkylation reactions, Journal of Catalysis, 2023, 425, 50-56, DOI: https://doi.org/10.1016/j.jcat.2023.05.025

6. Ana Xu; Chaoyi Li; Junrong Huang; Heng Pang; Chengyao Zhao; Lijuan Song; Hengzhi You; Xumu Zhang; Fen-Er Chen. Highly enantioselective synthesis of both tetrahydroquinoxalines and dihydroquinoxalinones via Rh–thiourea catalyzed asymmetric hydrogenation. Chemical Science, 2023, 14, 9024–9032, DOI: 10.1039/D3SC00803G

7. Jiaping Yu+; Jiaying Liu+; Chaoyi Li; Junrong Huang; Yuxiang Zhu; Hengzhi You;Recent advances and applications in high-throughput continuous flow; Chemical Communications, 2024, 60, 3217–3225; DOI:10.1039/D3CC06180A

8. Jun Li+; Junrong Huang+; Yan Wang; Yuexin Liu; Yuxiang Zhu; Hengzhi You; Fen-Er Chen. Copper-Catalyzed Asymmetric Allylic Substitution of Racemic/meso Substrates.Chemical Science, 2024, 15, 8280 - 8294, DOI: 10.1039/D4SC02135E

9. Junwen Wang; Feng Liang; Junrong Huang; Jun Li; Jingyuan Liao; Chengyao Zhao; Hengzhi You; Tao Tu; Fen-Er Chen. Amplifying enantioselectivity in asymmetric transformations using heterogeneous chiral single-rhodium-site catalyst with sustained catalytic activity. Chemical Engineering Journal, 2024-07, DOI: 10.1016/j.cej.2024.152387

10. Jun Li; Yu Wang; Yan Wang; Lianjie Zhai; Junrong Huang; Lijuan Song; Hengzhi You; Desymmetrization of Inert meso-Diethers through Copper-Catalyzed Asymmetric Allylic Alkylation with Grignard Reagents. Organic Letters, 2024, 26, 27, 5844–5849, DOI: 10.1021/acs.orglett.4c01972

11. Ana Xu; Lanxing Ren; Junrong Huang; Yuxiang Zhu; Gang Wang; Chaoyi Li; Yongqiang Sun; Lijuan Song; Hengzhi You; Fen-Er Chen. Highly enantioselective synthesis of both enantiomers of tetrahydroquinoxaline derivatives via Ir-catalyzed asymmetric hydrogenation. Chemical Science, 2024, 15, 15243 - 15254; DOI: 10.1039/D4SC04222K

12. Junwen Wang; Feng Liang; Zhen Dong; Junrong Huang; Yuxiang Zhu; Hengzhi You; Fen-Er Chen. Four-step continuous-flow total synthesis of (-)-debromoflustramine B using a chiral heterogeneous Pd NP catalyst. Chemical Science, 2024 | Journal article; DOI: 10.1039/D4SC03471F

13. Jingyuan Liao; Renrong Zhang; Xuelei Jia; Meiling Wang; Chaoyi Li; Juntao Wang; Renjin Tang; Junrong Huang; Hengzhi You; Fen-Er Chen. Green solvent mixture for ultrasound-assisted solid-phase peptide synthesis: a fast and versatile method and its applications in flow and natural product synthesis. Green Chemistry, 2024, 26, 10549 - 10557; DOI: 10.1039/D4GC03864A


2025年发表论文(通讯作者)

44. Rashed Rahman; Fazal Malik; Zaw Min Hein; Junrong Huang; Hengzhi You; Yuxiang Zhu,Continuous Flow Synthesis and Applications of Metal‐Organic Frameworks: Advances and Innovations, ChemPlusChem, 2025-01-03 | Journal article, DOI: 10.1002/cplu.202400634

43. Dongxuan He; Gang Wang; Binghan Li; Junrong Huang; Shuming Dou; Wei Gan; Hengzhi You; Qunhui Yuan,Ultrafast fabrication of Pd/C as a highly active and stable heterogeneous catalyst for hydrogenation synthesis of tris(hydroxymethyl)aminomethane under batch and flow, Surfaces and Interfaces, 2025-01 | Journal article, DOI: 10.1016/j.surfin.2024.105721


2024年发表论文(通讯作者)

42. Chaoyi Li, Minghao Su, Tianyi Hou, Yuhe Shi, Junrong Huang, Jing Qing, Wenxin Niu, Yinghe Zhang, Ling zhang, and Hengzhi You, Two new amino acid derivatives as green corrosion inhibitors against Q235 steel in HCl solution: Experimental and theoretical investigations, Int. J. Miner. Metall. Mater.,(2024).  DOI: https://dx.doi.org/10.1007/s12613-024-3011-8

41. Jingyuan Liao; Renrong Zhang; Xuelei Jia; Meiling Wang; Chaoyi Li; Juntao Wang; Renjin Tang; Junrong Huang; Hengzhi You; Fen-Er Chen. Green solvent mixture for ultrasound-assisted solid-phase peptide synthesis: a fast and versatile method and its applications in flow and natural product synthesis. Green Chemistry, 2024, 26, 10549 - 10557; DOI: 10.1039/D4GC03864A

40. Junwen Wang; Feng Liang; Zhen Dong; Junrong Huang; Yuxiang Zhu; Hengzhi You; Fen-Er Chen. Four-step continuous-flow total synthesis of (-)-debromoflustramine B using a chiral heterogeneous Pd NP catalyst. Chemical Science, 2024 | Journal article; DOI: 10.1039/D4SC03471F

39. Ana Xu; Lanxing Ren; Junrong Huang; Yuxiang Zhu; Gang Wang; Chaoyi Li; Yongqiang Sun; Lijuan Song; Hengzhi You; Fen-Er Chen. Highly enantioselective synthesis of both enantiomers of tetrahydroquinoxaline derivatives via Ir-catalyzed asymmetric hydrogenation. Chemical Science, 2024, 15, 15243 - 15254;DOI: 10.1039/D4SC04222K

38. Xiaowen Zhang; Yang Li; Chaoyi Li; Jingyuan Zhu; Zhiqiang Gan; Lei Wang; Xiaofei Sun; Hengzhi You; A chemical reaction entity recognition method based on a natural language data augmentation strategy. Chemical Communications, 2024, 60, 9610 - 9613; DOI: 10.1039/D4CC01471E

37. Jun Li; Yu Wang; Yan Wang; Lianjie Zhai; Junrong Huang; Lijuan Song; Hengzhi You; Desymmetrization of Inert meso-Diethers through Copper-Catalyzed Asymmetric Allylic Alkylation with Grignard Reagents. Organic Letters, 2024, 26, 27, 5844–5849, DOI: 10.1021/acs.orglett.4c01972

36. Junwen Wang; Feng Liang; Junrong Huang; Jun Li; Jingyuan Liao; Chengyao Zhao; Hengzhi You; Tao Tu; Fen-Er Chen. Amplifying enantioselectivity in asymmetric transformations using heterogeneous chiral single-rhodium-site catalyst with sustained catalytic activity. Chemical Engineering Journal, 2024-07, DOI: 10.1016/j.cej.2024.152387

35.  Jun Li+; Junrong Huang+; Yan Wang; Yuexin Liu; Yuxiang Zhu; Hengzhi You; Fen-Er Chen. Copper-Catalyzed Asymmetric Allylic Substitution ofRacemic/meso Substrates. Chemical Science, 2024, 15, 8280 - 8294, DOI: 10.1039/D4SC02135E

34. Jiaping Yu+; Jiaying Liu+; Chaoyi Li; Junrong Huang; Yuxiang Zhu; Hengzhi You;Recent advances and applications in high-throughput continuous flow; Chemical Communications, 2024, 60, 3217–3225; DOI:10.1039/D3CC06180A

33. 关东, 董珍, 陈凯, 李国威, 廖竞远, 黄均荣, 游恒志. L-10BPA中间体合成工艺优化及连续流可行性工艺研究 [J]. 当代化工研究 ,2023, (21):143-145.

32. Heng Pang+; Junrong Huang+; Juntao Wang; Gang Wang; Ana Xu; Lei Luo; Qunhui Yuan; Hengzhi You; Fen-Er Chen. Practical synthesis of tetrahydrofolate by highly efficient catalytic hydrogenation in continuous flow. Journal of Flow Chemistry (2024),  DOI:10.1007/s41981-024-00310-7


2023年发表论文(通讯作者)

31. Ana Xu; Chaoyi Li; Junrong Huang; Heng Pang; Chengyao Zhao; Lijuan Song; Hengzhi You; Xumu Zhang; Fen-Er Chen. Highly enantioselective synthesis of both tetrahydroquinoxalines and dihydroquinoxalinones via Rh–thiourea catalyzed asymmetric hydrogenation. Chemical Science, 2023, 14, 9024 - 9032, DOI: 10.1039/D3SC00803G

30. Lei Xu, Gang Wang, Nianxin Rong, Yang Gu, Le’an Hu, Hengzhi You and Qin Yin. Enantioselective and Step-Economic Synthesis of the Chiral Amine Fragment in the Tyrosine Kinase Inhibitor Repotrectinib by Direct Asymmetric Reductive Amination under Batch and Flow, Org. Process Res. Dev., 2023, DOI: 10.1021/acs.oprd.3c00152

29. Xiao Song, Jing Qing, Jun Li, Xuelei Jia, Fusong Wu, Junrong Huang, Jian Jin, Hengzhi You. Copper-catalyzed asymmetric allyl alkylation using Grignard reagents under flow, Chinese Journal of Organic Chemistry, 2023, DOI: 10.6023/cjoc202303027.

28. Chao Wang, Yan Wang, Xuelei Jia, Junrong Huang, Hengzhi You, Fen-Er Chen. Recyclable Silica-Support Taniaphos/Copper(Ⅰ) complex for asymmetric allylic alkylation reactions, Journal of Catalysis, 2023, 425, 50-56, DOI: https://doi.org/10.1016/j.jcat.2023.05.025

27. 卿晶,廖竞远,陈凯,代德胜,游恒志. 13C-尿素的合成工艺优化及连续流工艺研究 [J].当代化工研究,2023,(08):146-148.

26. Jun Li, Xiao Song, Yan Wang, Junrong Huang, Hengzhi You and Fen-Er Chen. Copper-Catalyzed Asymmetric Allylic Alkylation of Racemic Inert Cyclic Allylic Ethers under Batch and Flow. Chemical Science, 2023, 14, 4351–4356, DOI: 10.1039/D3SC00127J


2022年发表论文(通讯作者)

25. Jingyuan Liao; Xuelei Jia; Fusong Wu; Junrong Huang; Guifu Shen; Hengzhi You; Fen-Er Chen. Rapid mild macrocyclization of depsipeptides under continuous flow: total syntheses of five cyclodepsipeptides. Org. Chem. Front., 2022, Advance Article, DOI: 10.1039/D2QO01577C

24. Dongliang Zhang, Fusong Wu, Zhijian Wan, Yichun Wang, Xuan He, Bing Guo, Hengzhi You  and Fen-Er Chen. Palladium Polyaniline Complex: A Simple and Efficient Catalyst for Batch and Flow Suzuki-Miyaura Cross-couplings. Chemical Communications, 2022, DOI: 10.1039/D2CC04051D

23.  Jun Li, Xiao Song, Fusong Wu, Hengzhi You, and Fen-Er Chen. Cu-Catalyzed Asymmetric Allylic Alkylation of Racemic CyclicAllyl Bromides with Organolithium Compounds. Eur. J. Org. Chem.2022, e202200860;DOI: 10.1002/ejoc.202200860

22. Wang, J.,Li, J., Wang, Y., He, S., You, H. & Chen, F. Polymer-Supported Chiral Heterogeneous Copper Catalyst for Asymmetric Conjugate Addition of Ketones and Imines under Batch and Flow. ACS Catal. 9629–9637 (2022). DOI: 10.1021/acscatal.2c02056

21. Xiaofei Sun,Jingyuan Zhu,Bin Chen ,Hengzhi You ,Huiqing Xu;A feature transferring workflow between data-poor compounds in various tasks;Pols one; 202204;DOI: 10.1371/journal.pone.0266088

20.  Sun Xiaofei, Zhu Jingyuan, Chen Bin, You Hengzhi;融合多模态数据的药物合成反应的虚拟筛选;计算机应用;2022;DOI: 10.11772/j.issn.1001-9081.2021122228


2022年以前发表论文及非通讯作者论文

19.  Xiqi Li, Aijie Wang, Zhe Yu, Hualin Wang, Hengzhi You, Jifei Xu, Jingyu Zhang, Wenzong Liu; New understanding of microbial growth cycle for efficient waste-activated sludge disposal by preserving microbial self-degradation activity during the decline phase, Water Research X, Volume 27, 2025,100323, ISSN 2589-9147, https://doi.org/10.1016/j.wroa.2025.100323.

18.  Mingxing Nie; Zhengyu Xu; Yu Wang; Hengzhi You; Lei Luo; Binghan Li; Sadaf Mutahir; Wei Gan; Qunhui Yuan; Ultrafast synthesis of efficient TS-PtCoCu/CNTs composite with high feed-to-product conversion rate by Joule heating for electrocatalytic oxidation of ethanol; Journal of Colloid and Interface Science; 2024-04;DOI: 10.1016/j.jcis.2024.01.090

17. Yufeng Xie; Huaying Liu; Zhong-Liang Li; Xin Zhang; Lijuan Song; Kang Zhou; Feng Yuan; Hengzhi You; Engui Zhao; Zikai He; Construction of chiral through-space luminophores via symmetry breaking triggered by sequenced chlorination; Science China Chemistry; 202305 ;DOI: 10.21203/rs.3.rs-2258314/v1

16.   Jingyuan Liao, Shilong Zhang, Zesheng Wang, Xiao Song, Dongliang Zhang, Ravi Kumar, Jian Jin, Peng Ren, Hengzhi You, Fen-Er Chen;Transition-metal catalyzed asymmetric reactions under continuous flow from 2015 to early 2020;Green Synthesis and Catalysis;202008;DOI: 10.1016/j.gresc.2020.08.001

15.  Brij Mohan; Zhiyu Tao; Sandeep Kumar; Tiantian Xing; Shixuan Ma; Wenbin Huang; Xueping Yang; Hengzhi You; Peng Ren; Water- and pH-Stable Methylthio-Containing Metal–Organic Frameworks as Luminescent Sensors for Metal-Ion Detection; Crystal Growth & Design; 2022; DOI: 10.1021/acs.cgd.2c00493

14.  Mohan, B.,Kumar, S.,Xi, H.,Ma, S.,Tao, Z.,Xing, T.,You, H.,Zhang, Y.,Ren, P; Fabricated Metal-Organic Frameworks (MOFs) as luminescent and electrochemical biosensors for cancer biomarkers detection; Biosensors and Bioelectronics; 2022; DOI: 10.1016/j.bios.2021.113738

13.  Mohan, B.,Modi, K.,Parikh, J.,Ma, S.,Kumar, S.,Kumar Manar, K.,Sun, F.,You, H.,Ren, P; Efficacy of 2-nitrobenzylidene-hydrazine-based selective and rapid sensor for Cu2 ions, histidine, and tyrosine: Spectral and computational stud; Journal of Photochemistry and Photobiology A: Chemistry; 2022; DOI: 10.1016/j.jphotochem.2021.113557

12. Kumar, S.,Mohan, B.,Tao, Z.,You, H.,Ren, P; Incorporation of homogeneous organometallic catalysts into metal-organic frameworks for advanced heterogenization: A review; Catalysis Science and Technology; 2021; DOI: 10.1039/d1cy00663k

11.  Wan, Z.,Tao, Y.,You, H.,Zhang, X.,Shao, J; Na-ZSM-5 Zeolite Nanocrystals Supported Nickel Nanoparticles for Efficient Hydrogen Production from Ammonia Decomposition; ChemCatChem; 2021; DOI: 10.1002/cctc.202100324

10.  Wan, Z.,Tao, Y.,You, H.,Shao, J; Facile synthesis of a sintering-resistant zeolite confined Ni catalyst for efficient COx-free hydrogen generation from ammonia decomposition; Sustainable Energy and Fuels; 2021; DOI: 10.1039/d1se00417d

9.  Kumar, S.,Liu, S.,Mohan, B.,Zhang, M.,Tao, Z.,Wan, Z.,You, H.,Sun, F.,Li, M.,Ren, P; Fluorine-Containing Triazole-Decorated Silver(I)-Based Cationic Metal-Organic Framework for Separating Organic Dyes and Removing Oxoanions from Water; Inorganic Chemistry; 2021; DOI: 10.1021/acs.inorgchem.0c03688

8.  Mohan, B.,Kumar, S.,Ma, S.,You, H.,Ren, P; Mechanistic Insight into Charge and Energy Transfers of Luminescent Metal–Organic Frameworks Based Sensors for Toxic Chemicals; Advanced Sustainable Systems; 2021; DOI: 10.1002/adsu.202000293

7. Mohan, B.,Modi, K.,Patel, C.,Kumar, S.,Zhiyu, T.,You, H.,Ren, P; A new N-methylhydrazinecarbothioamide incorporated “naked-eye” and “turn-off” chemosensor for selective and low detection of Cu2 ions and computation study; Journal of Photochemistry and Photobiology A: Chemistry; 2021; DOI: 10.1016/j.jphotochem.2020.113097

6.  Wan, Z.,Tao, Y.,Shao, J.,Zhang, Y.,You, H; Ammonia as an effective hydrogen carrier and a clean fuel for solid oxide fuel cells; Energy Conversion and Management; 2021;DOI: 10.1016/j.enconman.2020.113729

5. Liu, F.,Kumar, S.,Li, S.,You, H.,Ren, P.,Zhao, L; Bifunctional design of stable metal-organic framework bearing triazole–carboxylate mixed ligand: Highly efficient heterogeneous catalyst for knoevenagel condensation reaction under mild conditions; Catalysis Communications; 2020; DOI: 10.1016/j.catcom.2020.106032

4.  Rideau, E., You, H., Sidera, M., Claridge, T. D. W. & Fletcher, S. P. Mechanistic studies on a Cu-catalyzed asymmetric allylic alkylation with cyclic racemic starting materials. J. Am. Chem. Soc. 139, 5614–5624 (2017).DOI: 10.1021/jacs.7b02440

3.  You, H., Rideau, E., Sidera, M. & Fletcher, S. P. Non-stabilized nucleophiles in Cu-catalysed dynamic kinetic asymmetric allylic alkylation. Nature. 517, 351–355 (2015).DOI: 10.1038/nature14089

2. Dai, Y.,Wu, F.,Zang, Z.,You, H.,Gong, H.;Ni-catalyzed reductive allylation of unactivated alkyl halides with allylic carbonates;Chemistry - A European Journal;2012;DOI: 10.1002/chem.201102984

1. Yin, H.,Zhao, C.,You, H.,Lin, K.,Gong, H.; Mild ketone formation via Ni-catalyzed reductive coupling of unactivated alkyl halides with acid anhydrides; Chemical Communications; 2012;DOI: 10.1039/c2cc33232a