教学科研系列

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基本信息

地址: 深圳市南山区西丽大学城哈工大校区D栋207室

邮箱: chenhuaying@hit.edu.cn

个人简介

陈华英,教授,博士生导师,本科毕业于山东大学材料科学与工程学院,于2012年在澳大利亚新南威尔士大学生物医学工程学院获博士学位。他自20122016年分别在昆士兰大学澳大利亚生物工程和纳米技术研究所和澳大利亚联邦科学与工业研究组织从事博士后研究,并于20166月入职哈尔滨工业大学(深圳)机电学院。陈华英博士主要从事微流控芯片在细胞分析和疾病快速检测领域的研究。主要研究兴趣包括:单细胞分析、疾病快速检测芯片、纸芯片等。现主持国家自然基金面上项目和青年项目各一项,深圳市自由探索项目三项。已授权发明专利13项,PCT专利1项,申请发明专利18项。在包括Analytical Chemistry, Trends in Analytical Chemistry, Nanoscale Lab on a Chip等的SCI刊物上发表论文五十多篇。此外,陈华英博士是广东省珠江计划青年拔尖人才,深圳市和珠海香洲区高层次人才,中国微纳协会高级会员,深圳微纳协会理事,中国生物医学工程学会高级会员。

研究方向

一、基于微流控的细胞分选分析装备 (Microfluidic-based cell analysis equipment)

二、基于AI技术和细胞形貌的高通量分选研究(Morphology-based cell sorting using AI image analysis)

三、微流控芯片在辅助生殖中的应用研究 (Microfluidics for Artificial Reproduction)

工作经历

哈尔滨工业大学(深圳)机电工程与自动化学院 教授

哈尔滨工业大学(深圳)机电工程与自动化学院 副教授
澳大利亚联邦科学与工业研究组织 博士后
澳大利亚昆士兰大学 澳大利亚生物工程与纳米技术研究所 博士后
山东大学材料科学与工程学院 辅导员

学习经历

澳大利亚新南威尔士大学 博士
山东大学材料科学与工程学院 硕士研究生
山东大学材料科学与工程学院 本科

科研项目

2023-2025 广东省自然基金面上项目 (主持)

2022-2025  国家自然科学基金面上项目(主持)

2021-2022  深圳市高等院校稳定支持计划项目(主持)

2019-2020  深圳市基础研究自由探索项目(主持)

2018-2020  国家自然科学基金青年项目(主持)

2018-2019  深圳市基础研究自由探索项目(主持)

2017-2019  深圳市人才启动项目:
2016-2019  哈工大(深圳)新教师科研启动项目(主持)

教学课程

主讲研究生课程《微纳尺度流体力学》  学位课  学时:32
开课时间:春季
主讲本科生课程《机械工程材料及成形技术》 必修课   学时:24
开课时间:秋季

主讲本科生课程《微纳制造技术》  选修课  学时:32
开课时间:秋季


论文及著作


SCI 论文:

(1)   Zheng Xu, Zhenlin Chen, Shiming Yang, Siyuan Chen, Tianruo Guo, Huaying Chen*.  Passive Focusing of Single Cells Using Microwell Arrays for High-Accuracy Image-Activated Sorting.Analytical Chemistry,2023.(中科院一区Top期刊, 影响因子: 7.4)

(2)   Zhihang Yu, Jing Jin, Siyuan Chen, Lingling Shui, Huaying Chen, Liuyong Shi, Yonggang Zhu*.  Smart Droplet Microfluidic System for Single-Cell Selective Lysis and Real-Time Sorting Based on Microinjection and Image Recognition.Analytical Chemistry,2023.(中科院一区Top期刊, 影响因子: 7.4)

(3)   Jiaming Shi, Wenqiang Tong, Zhihang Yu, Lei Tong, Huaying Chen, Jing Jin, Yonggang Zhu*.  Pollution-Free and Highly Sensitive Lactate Detection in Cell Culture Based on a Microfluidic Chip.Micromachines,2023.(中科院三区, 影响因子: 3.4)

(4)  Zheng Huang, Yuanhao Xie, Huaying Chen, Zhihang Yu, Liuyong Shi, Jing Jin*.  Fundamentals and Manipulation of Bare Droplets and Liquid Marbles as Open Microfluidic Platforms.Processes,2023.(中科院四区, 影响因子: 3.5)

(5)   Yike Cai, En Yu, Jing Jin, Ya Liu, Huaying Chen*.  Continuous trapping, elasticity measuring and deterministic printing of single cells using arrayed microfluidic traps.Lab on a Chip,2023.(中科院二区, 影响因子: 6.1)

(6)   Huaying Chen*, Haixu Meng, Zhenlin Chen, Tong Wang, Chuanpin Chen, Yonggang Zhu, and Jing Jin* Size-Based Sorting and In Situ Clonal Expansion of Single Cells using Microfluidics. Biosensors 2022, 12, 1100. JCR一区,影响因子:5.743

(7)  Chang Chen, Haixu Meng, Tianruo Guo, Siddharth Deshpande, and Huaying Chen*. Development of Paper Microfluidics with 3D-Printed PDMS Barriers for Flow Control. ACS Applied Materials & Interfaces, 2022.(中科院一区Top期刊,影响因子:10.383

(8)   Chang Chen, Panpan Li, Tianruo Guo, Siyuan Chen, Dong Xu, Huaying Chen*,Generation of Dynamic Concentration Profile Using A Microfluidic Device Integrating Pneumatic Microvalves. Biosensors, 2022, 13;12(10):868.(JCR一区,影响因子:5.743

(9)   Haixu Meng, Chang Chen, Yonggang Zhu, Zhengtu Li, Feng Ye, Joshua W.K. Ho, and Huaying Chen*. Automatic flow delay through passive wax valves for paper-based analytical devices. Lab on a Chip, 2021. (中科院一区Top期刊,影响因子:7.517

(10)   Zhenlin Chen, Yonggang Zhu, Dong Xu, Md.Mahbub Alam, Lingling Shui, and Huaying Chen*. Cell elasticity measurement using a microfluidic device with real-time pressure feedback. Lab on a Chip, 2020.(中科院一区Top期刊,影响因子:7.517

(11)   Chang Chen, Dong Xu, Siwei Bai, Zhihang Yu, Yonggang Zhu, Xiao Xing and Huaying Chen*. Dynamic screening and printing of single cells using a microfluidic chip with dual microvalves. Lab on a Chip, 2020. (中科院一区Top期刊,影响因子:7.517

(12)   Chaozhan Chen, Bin Ran, Zhenxing Wang, Hongli Zhao, Minbo Lan, Huaying Chen* and Yonggang Zhu*. Development of micropillar array electrodes for highly sensitive detection of biomarkers. RSC Advances. 2020. JCR二区,影响因子:4.036

(13)   Huaying Chen*, Zhihang Yu, Siwei Bai, Huaxiu Lu, Dong Xu, Chang Chen, Di Liu, Yonggang Zhu. Microfluidic models of physiological or pathological flow shear stress for cell biology, disease modeling and drug development. Trends in Analytical Chemistry, 2019. (中科院一区Top期刊,影响因子:14.908)

(14)   Chang Chen, Litao Zhao, Han Zhang, Xiaoshuang Shen, Yonggang Zhu and Huaying Chen*. Novel wax valves to improve distance-based analyte quantification in paper microfluidics. Analytical Chemistry, 2019. (中科院一区Top期刊影响因子:8.008)

(15)  Huaying Chen, Chang Chen, Siwei Bai, Yuan Gao, Guy Metcalfe, Wenlong Cheng and Yonggang Zhu*. Multiplexed detection of cancer biomarkers using a microfluidic platform integrating single bead trapping and acoustic mixing techniques. Nanoscale, 2018,43.JCR一区影响因子:8.307

(16)  Huaying Chen, Yuan Gao, Petkovic Karolina, Yan Sheng, Best Michael, Yanping Du and Yonggang Zhu*, Reproducible bubble-induced acoustic microstreaming for bead disaggregation and immunoassay in microfluidics. Microfluidics and Nanofluidics, 2017,21(3):30.JCR 二区,影响因子:3.090

(17)  Huaying Chen, Jane Sun, Ernst J. Wolvtang and Justin J. Cooper-White*, High-throughput, deterministic single cell trapping and long-term cell culture in microfluidic devices, Lab On a Chip, 2015, 15, 1072–1083.(中科院一区Top期刊影响因子:7.517

(18)  Huaying Chen, James Cornwell, Han Zhang, Tse Lim, Rena Resurreccion, Timothy Port, Gary Rosengarten, and Robert E Nordon*, Cardiac-like flow generator for long-term imaging of endothelial cell responses to circulatory pulsatile flow at microscale, Lab On a Chip, 2013, 13 15: 2999-3007. (中科院一区Top期刊影响因子:7.517

(19)  Huaying Chen, Gary Rosengarten, Musen Li, and Robert E. Nordon*, Design of microdevices for long-term live cell imaging, Journal of Micromechanics and Microengineering, 2012, 22 6: 065033.1-065033.10. JCR 三区,影响因子:2.282

(20)  Huaying Chen, Jingjing Li, Han Zhang, Musen Li, Gary Rosengarten, and Robert E. Nordon*, Microwell perfusion array for high-throughput, long-term imaging of clonal growth. Biomicrofluidics, 2011, 5 4: 044117.1-044117.12. JCR 二区,影响因子:3.258

(21)  Menghua Lyu, Xuyang Shi, Xiaopan Liu, Yang Liu, Xijun Zhu, Lijuan Liao, Hongyan Zhao, Na Sun, Shiyu Wang, Linzhe Chen, Linyuan Fan, Qumiao Xu, Qianqian Zhu, Kai Gao, Huaying Chen, Yonggang Zhu, Zida Li, Weijin Guo, Yue Zheng, Ying Gu, LongqiLiu*, Meiniang Wang*, and Ya Liu*. Generation and Screening of Antigen-Specific Nanobodies from Mammalian Cells Expressing the BCR Repertoire Library Using Droplet-Based Microfluidics. Analytical Chemistry, 2022.(中科院一区Top期刊,影响因子: 8.008

(22)  Yong Wang, Xiaoxia Liu, Chang Chen, Yuduo Chen, Yang Li, Heng Ye, Bo Wang, Huaying Chen, Jinhong Guo and Xing Ma*. Magnetic Nanorobots as Maneuverable Immunoassay Probes for Automated and Efficient Enzyme Linked Immunosorbent Assay. ASC Nano, 2022.(中科院一区Top期刊, 影响因子:18.027

(23)  Bo Liu, Bin Ran, Chaozhan Chen, Liuyong Shi, Ya Liu, Huaying Chen and Yonggang Zhu*. A low-cost and high-performance 3D micromixer over a wide working range and its application for high-sensitivity biomarker detection. Reaction Chemistry & Engineering, 2022.JCR二区,影响因子:5.200

(24)  Bin Ran, Chaozhan Chen, Bo Liu, Minbo Lan, Huaying Chen, Yonggang Zhu*. A Ti3C2TX/Pt–Pd based amperometric biosensor for sensitive cancer biomarker detection. Electrophoresis, 2022.JCR二区,影响因子:3.595

(25)  Zhihang Yu, Jing Jin, Lingling Shui, Huaying Chen, Yonggang Zhu*. Recent advances in microdroplet techniques for single-cell protein analysis. Trends in Analytical Chemistry, 2021, 143, 116411. (中科院一区Top期刊,影响因子:14.908)

(26) Penghui Guo, Wenxin Zeng, Sanping Tian, Huaying Chen, Wenfang Liu, Chuanpin Chen*. Quantitative detection of nanomolar drug using surface-enhanced Raman scattering combined with internal standard method and two-step centrifugation method. Microchemical Journal. 2020.JCR一区,影响因子:5.304

(27)  Bo Liu, Chuanwen Lv, Chaozhan Chen, Bin Ran, Minbo Lan, Huaying Chen and Yonggang Zhu*. Electrochemical Performance of Micropillar Array Electrodes in Microflows. Micromachines. 2020.  JCR二区,影响因子:3.523

(28)  Xiao Xing, Litao Zhao, Wenjie Zhang, Zhuo Wang, Huimin Su, Huaying Chen, Guohong Ma, Junfeng Dai and Wenjing Zhang*. Influence of a substrate on ultrafast interfacial charge transfer and dynamical interlayer excitons in monolayer WSe2/graphene heterostructures. Nanoscale. 2020. JCR一区,影响因子:8.307

(29) Jiaming Shi, Lei Tong, Wenqiang Tong, Huaying Chen, Minbo Lan, Xiaoxi Sun and Yonggang Zhu*. Current progress in long-term and continuous cell metabolite detection using microfluidics. Trends in Analytical Chemistry. 2019. (中科院一区Top期刊,影响因子:14.908

(30) Lim Wei Yap, Huaying Chen, Yuan Gao, Karolina Petkovic, Yan Liang, Kae Jye Si, Huanting Wang, Zhiyong Tang, Yonggang Zhu and Wenlong Cheng*. Bifunctional plasmonic-magnetic particles for an enhanced microfluidic SERS immunoassay. Nanoscale. 2017;9(23), 7822-7829.JCR一区,影响因子:8.307

(31)  Karolina Petkovic, Guy Metcalfe, Huaying Chen, Yuan Gao, Michael Best, D. Lester and Yonggang Zhu*, Rapid Detection of Hendra Virus Antibodies: An Integrated Device with Nanoparticle Assay and Chaotic Micromixing, Lab on a chip ,2016. (中科院一区Top期刊影响因子:7.517

(32)  Yanping Du, Nam Le, Dong Chen, Huaying Chen and Yonggang Zhu*, Thermal management of solar cells using a nanocoated heat pipe plate: an indoor experimental study, International Journal of Energy Research ,2016. 中科院一区,影响因子:4.672

(33)   Huihui Yuan, Bin Qian, Huaying Chen and Minbo Lan*, The influence of conditioning film on antifouling properties of the polyurethane film modified by chondroitin sulfate in urine. Applied Surface Science 426, 587-596, doi:10.1016/j.apsusc.2017.06.314 (2017). 中科院一区Top期刊,影响因子:7.392

(34)  Huihui Yuan, Jing Xue, Bin Qian, Huaying Chen, Yonggang Zhu and Minbo Lan*, Preparation and antifouling property of polyurethane film modified by chondroitin sulfate, Applied Surface Science, 2017, 394, 403-413. 中科院一区Top期刊,影响因子:7.392

(35)  Sheng Yan, Jun Zhang, Huaying Chen, Dan Yuan, GurselAlici, Haiping Du, Yonggang Zhu, and Weihua Li*, Development of a novel magnetophoresis-assisted hydrophoresis microdevice for rapid particle ordering, Biomedical Microdevices,2016,18,1-9. JCR 区,影响因子:3.783

(36)  Gleb E. Yakubov, Mauricio R. Bonilla, Huaying Chen, Monika S. Doblin, Antony Bacic, Michael J. Gidley and Jason R. Stokes *, Mapping nano-scale mechanical heterogeneity of primary plant cell walls, Journal of Experimental Botany, 2016, 67(9):2799-2816. 中科院一区Top期刊,影响因子:7.298

(37)  Sheng Yan, Jun Zhang, Huaying Chen, Gursel Alici, Haiping Du, Yonggang Zhu, Weihua Li*, Making a hydrophoretic focuser tunable using a diaphragm, Biomicrofluidics, 2015, 8(6):064115. JCR 区,影响因子:3.258

(38)  Drew M. Titmarsh, Huaying Chen, Nick R. Glass and Justin J. Cooper-White*, Microfluidic technology platforms: poised to accelerate development and translation of stem cell-derived therapies, STEM CELLS Translational Medicine, 2014, 3(1):81-90. JCR 影响因子:7.655

(39)  Drew M. Titmarsh, Huaying Chen, Ernst J. Wolvetang and Justin J. Cooper-White*, Arrayed cellular environments for stem cells and regenerative medicine, Biotechnology Journal, 2013,8 2: 167-179. JCR 区,影响因子:5.726



 

发明专利

    以第一发明人授权发明专利13项,申请发明专利18项,PCT专利2项。